Article

LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation

2019-10-11

Abstract excerpt

<h4>ABSTRACT</h4> Conotruncal malformations are a major cause of congenital heart defects in newborn infants. Recently, genetic screens in humans and mouse models have identified mutations in LRP2 as a novel cause of a common arterial trunk, a severe form of outflow tract (OFT) defect. Yet, the underlying mechanism why the morphogen receptor LRP2 is essential for OFT development remained unexplained. Studying LR...

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Literature Corpus work: c16ec8c2-1a63-57e6-b616-c215967dea9b
DOI: 10.1101/801910

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