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Delta-like ligand-4 mediated Notch signaling controls proliferation of second heart field progenitor cells by regulating Fgf8 expression

1 Jan 2020

Abstract excerpt

The role played by Notch pathway in cardiac progenitor cell biology remains to be elucidated. Delta-like ligand-4 (Dll4), the arterial-specific Notch ligand, is expressed by second heart field (SHF) progenitors at time-points crucial in SHF biology. Dll4-mediated Notch signaling is critically required for maintaining an adequate pool of SHF progenitors, such that Dll4 knockout results in reduction in...

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PMID: 32778568
DOI: 10.1242/dev.185249

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