Article

Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog/Gli Is Required for Tracheoesophageal Separation

2019-09-21

Abstract excerpt

<h4>SUMMARY</h4> The trachea and esophagus arise from the separation of a common foregut tube during early fetal development. Mutations in key signaling pathways such as Hedgehog (HH)/Gli can disrupt tracheoesophageal (TE) morphogenesis and cause life-threatening birth defects (TEDs), however the underlying cellular mechanisms are unknown. Here we use mouse and Xenopus to define the HH/Gli-dependent processes or...

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Literature Corpus work: 3d6a42a8-bf5a-5550-a9c6-3530d8e767dd
DOI: 10.1101/777664

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