Article
Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.
Development (Cambridge, England) - 1 Nov 2008
Zhang Jue, Lin Yongshun, Zhang Yongyou, Lan Yongsheng, Lin Chunhong, Moon Anne M, Schwartz Robert J, Martin James F, Wang Fen
Abstract excerpt
The cardiac outflow tract (OFT) is a developmentally complex structure derived from multiple lineages and is often defective in human congenital anomalies. Although emerging evidence shows that fibroblast growth factor (FGF) is essential for OFT development, the downstream pathways mediating FGF signaling in cardiac progenitors remain poorly understood. Here, we report that FRS2alpha (FRS2), an adaptor protein...
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