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Outflow Tract Formation—Embryonic Origins of Conotruncal Congenital Heart Disease

9 Apr 2021

Abstract excerpt

Anomalies in the cardiac outflow tract (OFT) are among the most frequent congenital heart defects (CHDs). During embryogenesis, the cardiac OFT is a dynamic structure at the arterial pole of the heart. Heart tube elongation occurs by addition of cells from pharyngeal, splanchnic mesoderm to both ends. These progenitor cells, termed the second heart field (SHF), were first identified twenty years ago as essential...

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PMID: 33918884
DOI: 10.3390/jcdd8040042

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