Back to search

Article

Metabolic control of mitochondrial plasticity and extracellular vesicle biology drives Cryptococcus neoformans virulence

2026-03-02

Abstract excerpt

Metabolic adaptation to nutrient stress is a key but poorly understood driver of fungal virulence. Here, we show that a dominant East Asian lineage of Cryptococcus neoformans (VNIa-5), which disproportionately infects immunocompetent hosts, has undergone lineage-specific rewiring of glucose-responsive stress pathways. Integrating population genomics, transcriptomics, and experimental infection models, we demonstr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c15629bd-d608-5d0b-97b5-ea7da6f7de57
DOI
10.64898/2026.03.02.708673
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Metabolic control of mitochondrial plasticity and extracellular vesicle biology drives Cryptococcus neoformans virulenceDOI 10.64898/2026.03.02.708673
Metabolic plasticity and virulence of <i>Cryptococcus neoformans</i> are regulated by mitochondrial homeostasisSemantic proximity
Phenotypic landscape of an invasive fungal pathogen reveals its unique biology.Semantic proximity
Phenotypic landscape of a fungal meningitis pathogen reveals its unique biologySemantic proximity
Population genomics and the evolution of virulence in the fungal pathogen <i>Cryptococcus neoformans</i>Semantic proximity
Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host ResponseSemantic proximity
Genomic variation across a clinical <i>Cryptococcus</i> population linked to disease outcomeSemantic proximity
Microevolutionary traits and comparative population genomics of the emerging pathogenic fungus Cryptococcus gattiiSemantic proximity
A unique cell wall synthetic response evoked by glucosamine determines pathogenicity-associated fungal cellular differentiationSemantic proximity
Transcriptional heterogeneity of <i>Cryptococcus gattii</i> VGII compared with non-VGII lineages underpins key pathogenicity pathwaysSemantic proximity
Reconstruction and exploitation of a dedicated Genome-Scale Metabolic Model of the human pathogen <i>C. neoformans</i>Semantic proximity
Genome restructuring and lineage diversification of<i>Cryptococcus neoformans</i>during chronic infection of human hostsSemantic proximity
Transcriptional Profiling of Patient Isolates Identifies a Novel TOR Regulatory Pathway in Cryptococcal VirulenceSemantic proximity
Select a neighboring publication to make it the new centre.