Article

Transcriptional Profiling of Patient Isolates Identifies a Novel TOR Regulatory Pathway in Cryptococcal Virulence

2018-07-13

Abstract excerpt

Human infection with Cryptococcus causes up to a quarter million AIDS-related deaths annually and is the most common cause of non-viral meningitis in the United States. As an opportunistic fungal pathogen, C. neoformans is distinguished by its ability to adapt to diverse host environments including plants, amoeba and mammals. In the present study, comparative transcriptomics of the fungus within human cerebrospi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa4ce705-3435-5877-bea5-535939ec2124
DOI: 10.1101/368738

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional Profiling of Patient Isolates Identifies a Novel TOR Regulatory Pathway in Cryptococcal VirulenceDOI 10.1101/368738Read

The Cryptococcus neoformans Transcriptome at the Site of Human MeningitisSemantic proximity Read

Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System.Semantic proximity Read

Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stressesSemantic proximity Read

Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host ResponseSemantic proximity Read

Phenotypic landscape of a fungal meningitis pathogen reveals its unique biologySemantic proximity Read

Transcriptional heterogeneity of <i>Cryptococcus gattii</i> VGII compared with non-VGII lineages underpins key pathogenicity pathwaysSemantic proximity Read

NMD-mediated control of Tor influences adaptation to nutrient and temperature conditions in <i>Cryptococcus neoformans</i>Semantic proximity Read

Unveil the transcriptional landscape at the Cryptococcus-host axis in mice and nonhuman primatesSemantic proximity Read

The SAGA and NuA4 component Tra1 regulates <i>Candida albicans</i> drug resistance and pathogenesisSemantic proximity Read

A trade-off between proliferation and defense in the fungal pathogen <i>Cryptococcus</i> at alkaline pH is controlled by the transcription factor GAT201Semantic proximity Read

Temporal transcriptional response of <i>Candida glabrata</i> during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and drug resistanceSemantic proximity Read

Global proteomic analysis of <i>Cryptococcus neoformans</i> clinical strains reveals significant differences between latent and lethal infectionSemantic proximity Read