Article

Transcriptional heterogeneity of <i>Cryptococcus gattii</i> VGII compared with non-VGII lineages underpins key pathogenicity pathways

2018-08-22

Abstract excerpt

Cryptococcus gattii is a pathogenic yeast of humans and other animals, which causes disease predominantly in immunocompetent hosts. Infection begins when aerosolized yeast or spores enter the body, triggering an immune response, including engulfment by macrophages. To understand the early transcriptional signals in both the yeast and its mammalian host, we performed a time-course dual RNA-seq experiment for four l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd24a446-ac61-5d06-96fd-8778ee19096a
DOI: 10.1101/396796

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional heterogeneity of <i>Cryptococcus gattii</i> VGII compared with non-VGII lineages underpins key pathogenicity pathwaysDOI 10.1101/396796Read

A trade-off between proliferation and defense in the fungal pathogen <i>Cryptococcus</i> at alkaline pH is controlled by the transcription factor GAT201Semantic proximity Read

Cryptococcus gattii Virulence Composite: Candidate Genes Revealed by Microarray Analysis of High and Less Virulent Vancouver Island Outbreak StrainsSemantic proximity Read

Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host ResponseSemantic proximity Read

Gene, virulence and related regulatory mechanisms in Cryptococcus gattii.Semantic proximity Read

Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stressesSemantic proximity Read

Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System.Semantic proximity Read

Transcriptional Profiling of Patient Isolates Identifies a Novel TOR Regulatory Pathway in Cryptococcal VirulenceSemantic proximity Read

The Cryptococcus neoformans Transcriptome at the Site of Human MeningitisSemantic proximity Read

A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformansSemantic proximity Read

Transcriptional landscape of trans‐kingdom communication between C andida albicans and S treptococcus gordoniiSemantic proximity Read

Phenotypic landscape of a fungal meningitis pathogen reveals its unique biologySemantic proximity Read

Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii.Semantic proximity Read