Article

Genomic variation across a clinical <i>Cryptococcus</i> population linked to disease outcome

2021-11-24

Abstract excerpt

Cryptococcus neoformans is the causative agent of cryptococcosis, a disease with poor patient outcomes, accounting for approximately 180,000 deaths each year. Patient outcomes may be impacted by the underlying genetics of the infecting isolate; however, our current understanding of how genetic diversity contributes to clinical outcomes is limited. Here, we leverage clinical, in vitro growth and genomic data for 28...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a318359e-96e2-54d5-8dad-848d6a09bb81
DOI: 10.1101/2021.11.22.469645

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic variation across a clinical <i>Cryptococcus</i> population linked to disease outcomeDOI 10.1101/2021.11.22.469645Read

Population genomics and the evolution of virulence in the fungal pathogen <i>Cryptococcus neoformans</i>Semantic proximity Read

Identification of pathogen genomic differences that impact human immune response and disease during <i>Cryptococcus neoformans</i> infectionSemantic proximity Read

Cryptococcus neoformans Genotypic Diversity and Disease Outcome among HIV Patients in AfricaSemantic proximity Read

Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans InfectionSemantic proximity Read

Genetic and environmental influences on the evolution of virulence in the HIV-associated opportunistic human fungal pathogen <i>Cryptococcus neoformans</i>Semantic proximity Read

Genetic diversity and microevolution in clinical Cryptococcus isolates from Cameroon.Semantic proximity Read

Single nucleotide polymorphisms are associated with strain-specific virulence differences among clinical isolates of Cryptococcus neoformans.Semantic proximity Read

Microevolutionary traits and comparative population genomics of the emerging pathogenic fungus Cryptococcus gattiiSemantic proximity Read

Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa.Semantic proximity Read

Deciphering the global genomic landscape of <i>C. neoformans</i> : Population dynamics, molecular epidemiology and genomic signatures of pathogenicitySemantic proximity Read

Impact of pathogen genetics on clinical phenotypes in a population of <i>Talaromyces marneffei</i> from VietnamSemantic proximity Read

Genetics of<i>Cryptococcus neoformans</i>Semantic proximity Read