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Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host Response

19 Apr 2016

Abstract excerpt

UNLABELLED: Cryptococcus neoformans is a ubiquitous, opportunistic fungal pathogen that kills over 600,000 people annually. Here, we report integrated computational and experimental investigations of the role and mechanisms of transcriptional regulation in cryptococcal infection. Major cryptococcal virulence traits include melanin production and the development of a large polysaccharide capsule upon host entry;...

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PMID: 27094327
DOI: 10.1128/mbio.00313-16

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