Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic landscape of an invasive fungal pathogen reveals its unique biology.

Cell - 24 Jul 2025

Boucher Michael J, Banerjee Sanjita, Joshi Meenakshi B, Wei Angela L, Nalley Matthew J, Huang Manning Y, Lei Susan, Ciranni Massimiliano, Condon Andrew, Langen Andreas, Goddard Thomas D, Caradonna Ippolito, Goranov Alexi I, Homer Christina M, Mortensen Yasaman, Petnic Sarah, Reilly Morgann C, Xiong Yi, Susa Katherine J, Pastore Vito Paolo, Zaro Balyn W, Madhani Hiten D

Abstract excerpt

Cryptococcus neoformans is the most common cause of fungal meningitis and the top-ranking WHO fungal priority pathogen. Only distantly related to model fungi, C. neoformans is also a powerful experimental system for exploring conserved eukaryotic mechanisms lost from specialist model yeast lineages. To decipher its biology globally, we constructed 4,328 gene deletions and measured-with exceptional precision-the...

Topics

Cryptococcus neoformans
Animals
Mice
Phenotype
Virulence
Cryptococcosis
Humans
Gene Deletion
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fungal Proteins

Female

Source

Open in PubMed Open full text

Identifiers

PMID: 40505656
DOI: 10.1016/j.cell.2025.05.017
PMCID: PMC12407185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-40505656-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic landscape of an invasive fungal pathogen reveals its unique biology.PMID 40505656Read ↗

Phenotypic landscape of a fungal meningitis pathogen reveals its unique biologySemantic proximity Read ↗

Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformansSemantic proximity Read ↗

Systematic functional profiling of transcription factor networks in Cryptococcus neoformansSemantic proximity Read ↗

Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformansSemantic proximity Read ↗

Transcription Factors and Intracellular Proteins Orchestrate Phenotypic Adaptation in Cryptococcus neoformans for Survival and Human InfectionsSemantic proximity Read ↗

Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stressesSemantic proximity Read ↗

Population genomics and the evolution of virulence in the fungal pathogen <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

Network-assisted genetic dissection of pathogenicity and drug resistance in the opportunistic human pathogenic fungus Cryptococcus neoformans.Semantic proximity Read ↗

The interplay of phenotype and genotype in Cryptococcus neoformans disease.Semantic proximity Read ↗

Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans InfectionSemantic proximity Read ↗

Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformansSemantic proximity Read ↗

<i>Cryptococcus neoformans</i> : A sugar-coated killer with designer genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.