Article

HSV-1 Delta ribonucleotide reductase as a Model to Investigate Molnupiravir-Induced Mutagenesis

2025-06-09

Abstract excerpt

<title>Abstract</title> <p>Molnupiravir, a nucleoside analog effective against RNA viruses such as Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), exerts antiviral effects primarily through lethal mutagenesis by incorporation into viral RNA. However, its ambiguous base-pairing properties raise concerns about potential mutagenesis via conversion to deoxycytidine diphosphate (dCDP) by cellular ri...

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Literature Corpus work: c152c796-1f95-581d-9739-d7a90e4518c3
DOI: 10.21203/rs.3.rs-6807930/v1

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