Article

Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis - the special case of molnupiravir

2021-11-04

Abstract excerpt

This review considers antiviral nucleoside analog drugs, including ribavirin, favipiravir, and molnupiravir, that induce genome error catastrophe in SARS-CoV or SARS-CoV-2 via lethal mutagenesis as a mode of action. In vitro data indicate that molnupiravir may be 100-times more potent as an antiviral agent than ribavirin or favipiravir. Molnupiravir has recently demonstrated efficacy in a phase 3 clinical trial. B...

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Literature Corpus work: 0f1c79e2-9716-588e-b9aa-2f6d4bf358a4
DOI: 10.22541/au.163603698.81246011/v1

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