Article

HIV Vpr modulates the host DNA damage response at two independent steps to damage DNA and repress double-strand DNA break repair

2020-04-26

Abstract excerpt

<h4>ABSTRACT</h4> The DNA damage response (DDR) is a signaling cascade that is vital to ensuring the fidelity of the host genome in the presence of genotoxic stress. Growing evidence has emphasized the importance of both activation and repression of the host DDR by diverse DNA and RNA viruses. Previous work has shown that HIV-1 is also capable of engaging the host DDR, primarily through the conserved accessory pr...

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Literature Corpus work: 17ffe868-3728-5580-8de2-5259a19409fa
DOI: 10.1101/2020.04.26.062349

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