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CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

30 Jun 2016

Abstract excerpt

Herpesviruses infect the majority of the human population and can cause significant morbidity and mortality. Herpes simplex virus (HSV) type 1 causes cold sores and herpes simplex keratitis, whereas HSV-2 is responsible for genital herpes. Human cytomegalovirus (HCMV) is the most common viral cause of congenital defects and is responsible for serious disease in immuno-compromised individuals. Epstein-Barr virus...

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PMID: 27362483
DOI: 10.1371/journal.ppat.1005701

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