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Article

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis.

Nature structural & molecular biology - 1 Sept 2021

Kabinger Florian, Stiller Carina, Schmitzová Jana, Dienemann Christian, Kokic Goran, Hillen Hauke S, Höbartner Claudia, Cramer Patrick

Abstract excerpt

Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA mutations and impairs SARS-CoV-2 replication in animal models and in humans. Here, we establish the molecular mechanisms underlying molnupiravir-induced RNA mutagenesis by the viral RNA-dependent RNA polymerase (RdRp). Biochemical...

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Identifiers

PMID: 34381216
DOI: 10.1038/s41594-021-00651-0
PMCID: PMC8437801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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