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Article

Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues

8 Jan 2008

Abstract excerpt

RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents acting through lethal mutagenesis. We have synthesized novel N-6-substituted purine analogues with ambiguous incorporation characteristics due to tautomerization...

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PMID: 18180344
DOI: 10.1128/aac.01056-07

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