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Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistance

2026-05-22

Abstract excerpt

<h4>ABSTRACT</h4> How host functions affect resistance to antiviral drugs is poorly understood. Ganciclovir, a chain-terminating nucleoside analog, is a first-line therapy against human cytomegalovirus, a widespread herpesvirus that causes life-threatening disease in immunocompromised individuals and newborns. Ganciclovir resistance, which is caused by mutations that affect the viral kinase, UL97 and/or the viral...

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Literature Corpus work
1cebeb44-9726-547e-9c9b-6aa03cab4393
DOI
10.64898/2026.05.21.726832
Open publication

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Host DNA repair factors empower a mechanism of antiviral nucleoside analog resistanceDOI 10.64898/2026.05.21.726832
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