Article

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

2021-05-11

Abstract excerpt

Molnupiravir is an orally available antiviral drug candidate that is in phase III trials for the treatment of COVID-19 patients 1,2 . Molnupiravir increases the frequency of viral RNA mutations 3,4 and impairs SARS-CoV-2 replication in animal models 4-6 and in patients 2 . Here we establish the molecular mechanisms that underlie molnupiravir-induced RNA mutagenesis by the RNA-dependent RNA polymerase (RdRp) of...

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Literature Corpus work: 2227dd4e-8ec5-5c43-b068-ebb74c1c7092
DOI: 10.1101/2021.05.11.443555

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