Article
From RNA World to SARS-CoV-2: The Edited Story of RNA Viral Evolution.
Cells - 20 Jun 2021
Kockler Zachary W, Gordenin Dmitry A
Abstract excerpt
The current SARS-CoV-2 pandemic underscores the importance of understanding the evolution of RNA genomes. While RNA is subject to the formation of similar lesions as DNA, the evolutionary and physiological impacts RNA lesions have on viral genomes are yet to be characterized. Lesions that may drive the evolution of RNA genomes can induce breaks that are repaired by recombination or can cause base substitution...
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