Article

IL4i1-sourced oncometabolites promote neuroblastoma cell survival

2025-08-10

Abstract excerpt

<h4>Summary</h4> High-risk neuroblastoma (NB) is driven by the amplification of MYCN in conjunction with additional oncogenic mutations in kinases such as ALK. NB cells require antioxidant responses to maintain redox balance and are highly sensitive to ferroptosis. Here, we show that metabolites derived from infiltrating immune cells expressing IL4i1, a secreted oxidoreductase, are potent suppressors of NB ferrop...

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Literature Corpus work: c100bcf6-7062-5760-8688-65db25002ae8
DOI: 10.1101/2025.08.07.669062

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