Article

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors

2024-06-28

Abstract excerpt

<h4> ABSTRACT </h4> Monocyte–derived macrophages (mo-macs) drive immunosuppression in the tumor microenvironment (TME) and tumor-enhanced myelopoiesis in the bone marrow (BM) fuels these populations. Here, we performed paired transcriptome and chromatin analysis over the continuum of BM myeloid progenitors, circulating monocytes, and tumor-infiltrating mo-macs in mice and in patients with lung cancer to identify...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40f17d91-9ba2-51d9-b969-48f4275c3cd7
DOI: 10.1101/2024.06.24.600383

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumorsDOI 10.1101/2024.06.24.600383Read

A stress-NRF2 response axis polarises tumor macrophages and undermines immunotherapySemantic proximity Read

KEAP1-Mutant Lung Cancers Weaken Anti-Tumor Immunity and Promote an M2-like Macrophage Phenotype.Semantic proximity Read

Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment.Semantic proximity Read

The epigenetic landscape of tumor-associated macrophages: orchestrating immune evasion in the tumor microenvironmentSemantic proximity Read

Regulatory Networks Shaping Human Tumor-Associated Macrophages In Vivo Identify MAFB as a Key Transcriptional DriverSemantic proximity Read

NFKBID Links SPP1⁺ Tumor-Associated Macrophages to CD8⁺ T-Cell Exhaustion and Immunotherapy Response in Lung AdenocarcinomaSemantic proximity Read

Programs, Origins, and Niches of Immunomodulatory Myeloid Cells in GliomasSemantic proximity Read

Critical role of CD206+ macrophages in promoting a cDC1-NK-CD8 T cell anti-tumor immune axisSemantic proximity Read

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer.Semantic proximity Read

Macrophages, Inflammation, and Lung Cancer.Semantic proximity Read

Redoxhigh phenotype mediated by KEAP1/STK11/SMARCA4/NRF2 mutations diminishes tissue-resident memory CD8+ T cells and attenuates the efficacy of immunotherapy in lung adenocarcinoma.Semantic proximity Read

Tumor macrophage functional heterogeneity can inform the development of novel cancer therapies.Semantic proximity Read