Article
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.
Nature - 1 Feb 2024
Freitas Florencio Porto, Alborzinia Hamed, Dos Santos Ancély Ferreira, Nepachalovich Palina, Pedrera Lohans, Zilka Omkar, Inague Alex, Klein Corinna, Aroua Nesrine, Kaushal Kamini, Kast Bettina, Lorenz Svenja M, Kunz Viktoria, Nehring Helene, Xavier da Silva Thamara N, Chen Zhiyi, Atici Sena, Doll Sebastian G, Schaefer Emily L, Ekpo Ifedapo, Schmitz Werner, Horling Aline, Imming Peter, Miyamoto Sayuri, Wehman Ann M, Genaro-Mattos Thiago C, Mirnics Karoly, Kumar Lokender, Klein-Seetharaman Judith, Meierjohann Svenja, Weigand Isabel, Kroiss Matthias, Bornkamm Georg W, Gomes Fernando, Netto Luis Eduardo Soares, Sathian Manjima B, Konrad David B, Covey Douglas F, Michalke Bernhard, Bommert Kurt, Bargou Ralf C, Garcia-Saez Ana, Pratt Derek A, Fedorova Maria, Trumpp Andreas, Conrad Marcus, Friedmann Angeli José Pedro
Abstract excerpt
Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation that tumours exploit to counteract phospholipid oxidation1,2. Here, we identify proferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected prosurvival function of its substrate,...
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