Article

<i>In vivo</i> metabolomics identifies CD38 as an emergent vulnerability in <i>LKB1</i> -mutant lung cancer

2023-04-20

Abstract excerpt

<h4>ABSTRACT</h4> LKB1/STK11 is a serine/threonine kinase that plays a major role in controlling cell metabolism, resulting in potential therapeutic vulnerabilities in LKB1-mutant cancers. Here, we identify the NAD + degrading ectoenzyme, CD38, as a new target in LKB1-mutant NSCLC. Metabolic profiling of genetically engineered mouse models (GEMMs) revealed that LKB1 mutant lung cancers have a striking increase i...

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Literature Corpus work: f8d0fc2f-dd77-5386-a38a-746ed0755e10
DOI: 10.1101/2023.04.18.537350

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