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Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL)

2025-08-11

Abstract excerpt

<title>Abstract</title> <p>Diffuse large B-cell lymphoma (DLBCL) exhibits marked clinical heterogeneity and frequent treatment resistance, particularly in molecularly defined high-risk subtypes such as ABC-DLBCL. While current therapies largely rely on apoptosis induction, non-apoptotic cell death pathways remain underexplored in hematologic malignancies. Here, we identify ferroptosis, an iron-dependent, lipid pe...

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Literature Corpus work
bf5a5478-272f-5eda-8411-b2b9e2ca7aef
DOI
10.21203/rs.3.rs-7038817/v1
Open publication

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Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL)DOI 10.21203/rs.3.rs-7038817/v1
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