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Article

Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes.

Journal of molecular and cellular cardiology - 1 Nov 2016

Mann Stefan A, Imtiaz Mohammad, Winbo Annika, Rydberg Annika, Perry Matthew D, Couderc Jean-Philippe, Polonsky Bronislava, McNitt Scott, Zareba Wojciech, Hill Adam P, Vandenberg Jamie I

Abstract excerpt

In-silico models of human cardiac electrophysiology are now being considered for prediction of cardiotoxicity as part of the preclinical assessment phase of all new drugs. We ask the question whether any of the available models are actually fit for this purpose. We tested three models of the human ventricular action potential, the O'hara-Rudy (ORD11), the Grandi-Bers (GB10) and the Ten Tusscher (TT06) models. We...

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Identifiers

PMID: 27663173
DOI: 10.1016/j.yjmcc.2016.09.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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