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Article

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide.

Journal of molecular and cellular cardiology - 1 Sept 2015

Melgari Dario, Zhang Yihong, El Harchi Aziza, Dempsey Christopher E, Hancox Jules C

Abstract excerpt

The class Ic antiarrhythmic drug flecainide inhibits KCNH2-encoded "hERG" potassium channels at clinically relevant concentrations. The aim of this study was to elucidate the underlying molecular basis of this action. Patch clamp recordings of hERG current (IhERG) were made from hERG expressing cells at 37°C. Wild-type (WT) IhERG was inhibited with an IC50 of 1.49μM and this was not significantly altered by...

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Source

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Identifiers

PMID: 26159617
DOI: 10.1016/j.yjmcc.2015.06.021
PMCID: PMC4564290

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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