Article

Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics

2017-03-13

Abstract excerpt

Understanding the roles of ion currents is crucial to predict the action of pharmaceuticals and mutations in different scenarios, and thereby to guide clinical interventions in the heart, brain and other electrophysiological systems. Our ability to predict how ion currents contribute to cellular electrophysiology is in turn critically dependent on our characterisation of ion channel kinetics — the voltage-dependen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9fd1cf8f-88e0-5ff4-9b5a-cb4f33409bb1
DOI: 10.1101/100677

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sinusoidal voltage protocols for rapid characterisation of ion channel kineticsDOI 10.1101/100677Read

Four ways to fit an ion channel modelSemantic proximity Read

Computational biology in the study of cardiac ion channels and cell electrophysiology.Semantic proximity Read

Optimising experimental designs for model selection of ion channel drug binding mechanismsSemantic proximity Read

Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordingsSemantic proximity Read

From ionic to cellular variability in human atrial myocytes: an integrative computational and experimental study.Semantic proximity Read

Large-scale synthetic data enable digital twins of human excitable cellsSemantic proximity Read

Ion Channels: History, Diversity, and Impact.Semantic proximity Read

KICA: A MATLAB package for high-throughput analysis of calcium and voltage imaging data from cardiac cellsSemantic proximity Read

Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia.Semantic proximity Read

[Ionic channel pathies].Semantic proximity Read

A novel ionic model for matured and paced atrial–like hiPSC–CMs integrating <i>I</i> <sub> <i>Kur</i> </sub> and <i>I</i> <sub> <i>KCa</i> </sub> currentsSemantic proximity Read

Ca2+ and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor StimulationSemantic proximity Read