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Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant <i>Clostridioides difficile</i>

2022-09-24

Abstract excerpt

Severe outbreaks and deaths have been linked to the emergence and global spread of fluoroquinolone-resistant Clostridioides difficile over the past two decades. At the same time, metronidazole, a nitro-containing antibiotic, has shown decreasing clinical efficacy in treating C. difficile infection (CDI). Most metronidazole-resistant C. difficile exhibit an unusual resistance phenotype that can only be detected...

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Literature Corpus work
7e82cafb-f9ef-56cb-93d9-1921b635338e
DOI
10.1101/2022.09.23.509282
Open publication

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Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant <i>Clostridioides difficile</i>DOI 10.1101/2022.09.23.509282
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