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Article

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility.

Nature communications - 23 Sept 2020

Harding Clare R, Sidik Saima M, Petrova Boryana, Gnädig Nina F, Okombo John, Herneisen Alice L, Ward Kurt E, Markus Benedikt M, Boydston Elizabeth A, Fidock David A, Lourido Sebastian

Abstract excerpt

Artemisinins have revolutionized the treatment of Plasmodium falciparum malaria; however, resistance threatens to undermine global control efforts. To broadly explore artemisinin susceptibility in apicomplexan parasites, we employ genome-scale CRISPR screens recently developed for Toxoplasma gondii to discover sensitizing and desensitizing mutations. Using a sublethal concentration of dihydroartemisinin (DHA), we...

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Identifiers

PMID: 32968076
DOI: 10.1038/s41467-020-18624-0
PMCID: PMC7511413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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