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Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

12 Jul 2023

Abstract excerpt

Abstract Severe outbreaks and deaths have been linked to the emergence and global spread of fluoroquinolone-resistant Clostridioides difficile over the past two decades. At the same time, metronidazole, a nitro-containing antibiotic, has shown decreasing clinical efficacy in treating C. difficile infection (CDI). Most metronidazole-resistant C. difficile exhibit an unusual resistance phenotype that can only be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37438331
DOI: 10.1038/s41467-023-39429-x

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