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Chromosomal Resistance to Metronidazole in <i>Clostridioides difficile</i> can be Mediated By Epistasis Between Iron Homeostasis and Oxidoreductases

2020-03-05

Abstract excerpt

Chromosomal resistance to metronidazole has emerged in clinical Clostridioides difficile , but the genetic mechanisms remain unclear. This is further hindered by the inability to generate spontaneous metronidazole-resistant mutants in the lab to aid genetic studies. We therefore constructed a mismatch repair mutator, in non-toxigenic ATCC 700057, to unbiasedly survey the mutational landscape for de novo resistan...

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Literature Corpus work
bddd2d72-d04d-508b-a4c1-0cf0d8eb5a64
DOI
10.1101/2020.03.04.977868
Open publication

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Chromosomal Resistance to Metronidazole in <i>Clostridioides difficile</i> can be Mediated By Epistasis Between Iron Homeostasis and OxidoreductasesDOI 10.1101/2020.03.04.977868
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