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Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines

17 Mar 2017

Abstract excerpt

Giardia duodenalis is an intestinal parasite that causes 200-300 million episodes of diarrhoea annually. Metronidazole (Mtz) is a front-line anti-giardial, but treatment failure is common and clinical resistance has been demonstrated. Mtz is thought to be activated within the parasite by oxidoreductase enzymes, and kill through oxidative damage. In G. duodenalis, Mtz resistance involves active and passive...

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PMID: 28367140
DOI: 10.3389/fmicb.2017.00398

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