Article

SIN3 acts in distinct complexes to regulate the germline transcriptional program in <i>C. elegans</i>

2023-03-08

Abstract excerpt

The SIN3 transcriptional coregulator influences gene expression through multiple interactions that include histone deacetylases (HDACs). Haploinsufficiency and mutations in SIN3 are the underlying cause of Witteveen-Kolk syndrome and related intellectual disability (ID)/autism syndromes, emphasizing its key role in development. However, little is known about the diversity of its interactions and functions in devel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2869e9fd-b755-57eb-8e2d-89851085f8c4
DOI: 10.1101/2023.03.07.531480

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SIN3 acts in distinct complexes to regulate the germline transcriptional program in <i>C. elegans</i>DOI 10.1101/2023.03.07.531480Read

Overlapping and non-overlapping roles of the class-I histone deacetylase-1 corepressors, LET-418, SIN-3, and SPR-1 in <i>Caenorhabditis elegans</i> embryonic developmentSemantic proximity Read

Haploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism spectrum disorder.Semantic proximity Read

The <i>C. elegans</i> SET-2 histone methyltransferase maintains germline fate by preventing progressive transcriptomic deregulation across generationsSemantic proximity Read

Drosophila SIN3 is required at multiple stages of development.Semantic proximity Read

<i>C. elegans</i> synMuv B proteins regulate spatial and temporal chromatin compaction during developmentSemantic proximity Read

Exogenous expression of a histone H3.3 isoform causes extranuclear divisions in the <i>C. elegans</i> intestineSemantic proximity Read

Developmental functions for the Caenorhabditis elegans Sp protein SPTF-3.Semantic proximity Read

Functional Interplay of Two Paralogs Encoding SWI/SNF Chromatin-Remodeling Accessory Subunits During Caenorhabditis elegans Development.Semantic proximity Read

SNPC-1.3 is a sex-specific transcription factor that drives male piRNA expression in <i>C. elegans</i>Semantic proximity Read

Sperm-inherited H3K27me3 impacts offspring transcription and development in C. elegansSemantic proximity Read

Caenorhabditis elegans SWI/SNF subunits control sequential developmental stages in the somatic gonad.Semantic proximity Read

Developmentally programmed epigenome regulates cellular plasticity at the parental-to-zygote transitionSemantic proximity Read