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Article

Antagonism between MES-4 and Polycomb repressive complex 2 promotes appropriate gene expression in C. elegans germ cells.

Cell reports - 29 Nov 2012

Gaydos Laura J, Rechtsteiner Andreas, Egelhofer Thea A, Carroll Coleen R, Strome Susan

Abstract excerpt

The Caenorhabditis elegans MES proteins are key chromatin regulators of the germline. MES-2, MES-3, and MES-6 form the C. elegans Polycomb repressive complex 2 and generate repressive H3K27me3. MES-4 generates H3K36me3 on germline-expressed genes. Transcript profiling of dissected mutant germlines revealed that MES-2/3/6 and MES-4 cooperate to promote the expression of germline genes and repress the X chromosomes...

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Identifiers

PMID: 23103171
DOI: 10.1016/j.celrep.2012.09.019
PMCID: PMC3513488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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