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Article

Retroelement co-option disrupts the cancer transcriptional programme

2025-02-27

Abstract excerpt

<h4>Background</h4> Transcriptional activation of otherwise repressed endogenous retroelements (RTEs) is a hallmark of cancer, shaping tumour progression and immunogenicity by multifaceted, yet incompletely understood mechanisms. <h4>Methods</h4> We used an extended pan-cancer transcriptome assembly to identify potential effects of RTEs on the genes near or within which they have integrated. These were subsequen...

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Literature Corpus work
de6ce7fc-2198-5881-a811-ed0ad5d905d0
DOI
10.1101/2025.02.21.639580
Open publication

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Retroelement co-option disrupts the cancer transcriptional programmeDOI 10.1101/2025.02.21.639580
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