Article
Large-scale phenome-wide association study of <i>PCSK9</i> loss-of-function variants demonstrates protection against ischemic stroke
2017-10-27
Abstract excerpt
PCSK9 inhibitors are a potent new therapy for hypercholesterolemia and have been shown to decrease risk of coronary heart disease. Although short-term clinical trial results have not demonstrated major adverse effects, long-term data will not be available for some time. Genetic studies in large well-phenotyped biobanks offer a unique opportunity to predict drug effects and provide context for the evaluation of fut...
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Identifiers and source
- Literature Corpus work
- c0941258-b48e-5e8b-bf9e-ff492f74a54d
- DOI
- 10.1101/210302