Article

<i>PCSK9</i> genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study

2018-05-31

Abstract excerpt

<h4>Aims</h4> PCSK9 inhibitors lower LDL cholesterol and are efficacious at reducing risk of vascular disease, however questions remain about potential adverse effects on cognitive function. We examined the association of LDL cholesterol-lowering genetic variants in PCSK9 with continuous measures of cognitive ability <h4>Methods and Results</h4> Six independent SNPs in PCSK9 were used in up to 337,348 individ...

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Literature Corpus work: d207d6c9-2247-5e34-9899-36f2e7313a46
DOI: 10.1101/335877

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