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Article

PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort.

PloS one - 1 Jan 2020

Small Aeron M, Huffman Jennifer E, Klarin Derek, Lynch Julie A, Assimes Themistocles, DuVall Scott, Sun Yan V, Shere Labiba, Natarajan Pradeep, Gaziano Michael, Rader Daniel J, Wilson Peter W F, Tsao Philip S, Chang Kyong-Mi, Cho Kelly, O'Donnell Christopher J, Casas Juan P, Damrauer Scott M

Abstract excerpt

BACKGROUND: Therapeutic inhibition of PCSK9 protects against coronary artery disease (CAD) and ischemic stroke (IS). The impact on other diseases remains less well characterized. METHODS: We created a genetic risk score (GRS) for PCSK9 using four single nucleotide polymorphisms (SNPs) at or near the PCSK9 locus known to impact lower LDL-Cholesterol (LDL-C): rs11583680, rs11591147, rs2479409, and rs11206510. We...

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Share to Cholesterol, LDL
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Identifiers

PMID: 33166319
DOI: 10.1371/journal.pone.0239752
PMCID: PMC7652310

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