Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke.

doi:10.1093/eurheartj/ehx373

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Article

Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke.

European heart journal - 1 Feb 2018

Hopewell Jemma C, Malik Rainer, Valdés-Márquez Elsa, Worrall Bradford B, Collins Rory

Abstract excerpt

Aims: PCSK9 genetic variants that have large effects on low-density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD) have prompted the development of therapeutic PCSK9-inhibition. However, there is limited evidence that PCSK9 variants are associated with ischaemic stroke (IS). Methods and results: Associations of the loss-of-function PCSK9 genetic variant (rs11591147; R46L), and five additional...

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Identifiers

PMID: 29020353
DOI: 10.1093/eurheartj/ehx373
PMCID: PMC5837489

Genes

PCSK9

Variants

rs11591147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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