Article

Protective lipid-lowering genetic variants in healthy older individuals without coronary heart disease

2021-02-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Disruptive genetic variants in the PCSK9 and APOB genes result in lower serum low-density lipoprotein cholesterol (LDL-C) levels and confer protection against coronary heart disease (CHD). Few studies have measured the prevalence and selective advantage of such variants among healthy older individuals without prior CHD events. <h4>Methods and Results</h4> We performed targeted...

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Literature Corpus work: fd10229e-450c-5949-93be-6268a748ef36
DOI: 10.1101/2021.02.16.21251811

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