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Article

Protective lipid-lowering variants in healthy older individuals without coronary heart disease.

Open heart - 1 Jul 2021

Lacaze Paul, Riaz Moeen, Sebra Robert, Hooper Amanda J, Pang Jing, Tiller Jane, Polekhina Galina, Tonkin Andrew, Reid Chris, Zoungas Sophia, Murray Anne M, Nicholls Stephen, Watts Gerald, Schadt Eric, McNeil John J

Abstract excerpt

OBJECTIVE: Genetic variants that disrupt the function of the PCSK9 (proprotein convertase subtilisin kexin type 9) and APOB (apolipoprotein B)genes result in lower serum low-density lipoprotein cholesterol (LDL-C) levels and subsequently confer protection against coronary heart disease (CHD). The objective of this study was to measure the prevalence and selective advantage of such variants among healthy older...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34341098
DOI: 10.1136/openhrt-2021-001710
PMCID: PMC8330577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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