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Article

A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR

11 Feb 2019

Abstract excerpt

Abstract We conducted an electronic health record (EHR)-based phenome-wide association study (PheWAS) to discover pleiotropic effects of variants in three lipoprotein metabolism genesPCSK9,APOB, andLDLR. Using high-density genotype data, we tested the associations of variants in the three genes with 1232 EHR-derived binary phecodes in 51,700 European-ancestry (EA) individuals and 585 phecodes in 10,276...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30774981
DOI: 10.1038/s41525-019-0078-7

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