Article
Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation.
Nature communications - 1 Oct 2020
Xin Jingxue, Zhang Hui, He Yaoxi, Duren Zhana, Bai Caijuan, Chen Lang, Luo Xin, Yan Dong-Sheng, Zhang Chaoyu, Zhu Xiang, Yuan Qiuyue, Feng Zhanying, Cui Chaoying, Qi Xuebin, Ouzhuluobu, Wong Wing Hung, Wang Yong, Su Bing
Abstract excerpt
High-altitude adaptation of Tibetans represents a remarkable case of natural selection during recent human evolution. Previous genome-wide scans found many non-coding variants under selection, suggesting a pressing need to understand the functional role of non-coding regulatory elements (REs). Here, we generate time courses of paired ATAC-seq and RNA-seq data on cultured HUVECs under hypoxic and normoxic...
Topics
- Acclimatization
- Altitude
- Altitude Sickness
- Basic Helix-Loop-Helix Transcription Factors
- Cell Hypoxia
- Cells, Cultured
- Chromatin
- Chromatin Immunoprecipitation Sequencing
- Disease Resistance