Article

The transcription factor AP-2β defines active enhancers conferring molecular apocrine cell identity in breast cancer

2025-07-09

Abstract excerpt

The transcription factor Activating Protein 2β ( TFAP2B ; AP-2β) is a candidate marker for the molecular apocrine subtype of breast cancer, which lacks expression of the estrogen receptor alpha ( ESR1 ; ER) but sustains a luminal breast cancer phenotype due to the presence of key luminal lineage transcription factors (GATA3, FOXA1) and activity of the androgen receptor (AR). Our objective was to better understan...

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Literature Corpus work: c05cc9c9-726e-5290-8450-29727ad557b0
DOI: 10.1101/2025.07.05.663274

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