Article

Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin opening

2022-09-06

Abstract excerpt

Overexpression of the human epidermal growth factor 2 (HER2) protein in breast cancer patients is a predictor of poor prognosis and resistance to therapies. Despite significant advances in the development of targeted therapies and improvements in the 5-year survival rate of metastatic HER2-positive breast cancer patients, a better understanding of the disease at an early stage is needed to prevent its progression....

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Literature Corpus work: 03e294b3-aef9-5924-aff4-e53629a0ff43
DOI: 10.1101/2022.09.06.506760

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