Article

Classification of breast tumours into molecular apocrine, luminal and basal groups based on an explicit biological model

2018-02-23

Abstract excerpt

<h4>ABSTRACT</h4> The gene expression profiles of human breast tumours fall into three main groups that have been called luminal, basal and either HER2-enriched or molecular apocrine. To escape from the circularity of descriptive classifications based purely on gene signatures I describe a biological classification based on a model of the mammary lineage. In this model I propose that the third group is a tumour d...

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Literature Corpus work: 1189931e-f864-5ddd-a453-13472d0b0cb6
DOI: 10.1101/270975

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