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Article

DAB2IP loss in luminal a breast cancer leads to NF-κB-associated aggressive oncogenic phenotypes.

JCI insight - 6 Dec 2024

Mukherjee Angana, Kakati Rasha T, Van Alsten Sarah, Laws Tyler, Ebbs Aaron L, Hollern Daniel P, Spanheimer Philip M, Hoadley Katherine A, Troester Melissa A, Simon Jeremy M, Baldwin Albert S

Abstract excerpt

Despite proven therapy options for estrogen receptor-positive (ER+) breast tumors, a substantial number of patients with ER+ breast cancer exhibit relapse with associated metastasis. Loss of expression of RasGAPs leads to poor outcomes in several cancers, including breast cancer. Mining the The Cancer Genome Atlas (TCGA) breast cancer RNA-Seq dataset revealed that low expression of the RasGAP DAB2IP was...

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Share to Breast Neoplasms
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Gene Expression Regulation, Neoplastic

Share to NF-kappa B

Share to ras GTPase-Activating Proteins

Share to Receptors, Estrogen

Share to Signal Transduction

Source

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Identifiers

PMID: 39418101
DOI: 10.1172/jci.insight.171705
PMCID: PMC11623953

Genes

DAB2IP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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