Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low HER2 expression in normal breast epithelium enables dedifferentiation and malignant transformation via chromatin opening

20 Jan 2023

Abstract excerpt

Overexpression of the HER2 protein in breast cancer patients is a predictor of poor prognosis and resistance to therapies. We used an inducible breast cancer transformation system that allows investigation of early molecular changes. HER2 overexpression to similar levels as those observed in a subtype of HER2-positive breast cancer patients induced transformation of MCF10A cells and resulted in gross...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Genomics and Chromatin Dynamics
Share to HER2/EGFR in Cancer Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36661191
DOI: 10.1242/dmm.049894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low HER2 expression in normal breast epithelium enables dedifferentiation and malignant transformation via chromatin openingPMID 36661191Read ↗

Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin openingSemantic proximity Read ↗

BRCA1 and BRCA2 germline mutations driven signaling pathway alterations are sufficient to initiate breast tumorigenesis by the PIK3CA <sup>H1047R</sup> oncogeneSemantic proximity Read ↗

Cell Reprogramming in Tumorigenesis and Its Therapeutic Implications for Breast CancerSemantic proximity Read ↗

Signaling Pathway Alterations Driven by BRCA1 and BRCA2 Germline Mutations are Sufficient to Initiate Breast Tumorigenesis by the PIK3CAH1047R OncogeneSemantic proximity Read ↗

Nanolipoprotein mediated Her2 protein transfection induces malignant transformation in human breast acinar culturesSemantic proximity Read ↗

Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesisSemantic proximity Read ↗

Disruption of the epigenetic regulator BAP1 drives chromatin remodeling leading to the emergence of cells with breast cancer stem cell properties and aberrant glycosylationSemantic proximity Read ↗

Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model.Semantic proximity Read ↗

Oncogenic transformation proceeds through a transient state of cellular plasticity constrained by lineage-specific barriersSemantic proximity Read ↗

Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast CancerSemantic proximity Read ↗

Oncogenic transformation of normal breast epithelial cells co-cultured with cancer cellsSemantic proximity Read ↗

Mammary Tumor Formation and Metastasis Evoked by a HER2 Splice VariantSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.