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Article

Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells.

BMC cancer - 11 May 2010

Thewes Verena, Orso Francesca, Jäger Richard, Eckert Dawid, Schäfer Sabine, Kirfel Gregor, Garbe Stephan, Taverna Daniela, Schorle Hubert

Abstract excerpt

BACKGROUND: Activator protein-2 (AP-2) transcription factors are critically involved in a variety of fundamental cellular processes such as proliferation, differentiation and apoptosis and have also been implicated in carcinogenesis. Expression of the family members AP-2alpha and AP-2gamma is particularly well documented in malignancies of the female breast. Despite increasing evaluation of single AP-2 isoforms...

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Identifiers

PMID: 20459791
DOI: 10.1186/1471-2407-10-192
PMCID: PMC2890516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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